The deterioration of joints and the inflammation of the synovial bursa represent the mechanism through which the condition generally known as “arthrosis” affects the patients’ quality of life. Basically, as the articular tissue is destroyed, pieces of it get into the space between the articulations thus leading to severe inflammation. Whether we are talking about gonarthrosis, cervical arthrosis, coxarthrosis, articular facets arthrosis, or lumbar ostheoarthritis the ozone treatments act in two ways: the recovery of the damaged tissue in the joints and the reduction of the inflammation. A third mechanism has effect on the symptoms of arthrosis, namely pain and stiffness accompanied by the drastic reduction of mobility.

The reduction of the inflammation is done with the help of major autohemotransfusion. Clinical studies, quoted by scientific articles, prove that ozone treatment by major autohemotransfusion increases tissue oxygenation throughout the entire body and has effect in metabolizing the arachidonic acid by reducing the production of compounds that favour inflammation released in the blood stream. At the same time, administred in this way (by collecting 100ml of blood, enriching it with ozone by bubbling and reinjecting it through an IV), ozone reduces the levels of total cholesterol, LDL-cholesterol and triglycerides. Since arthrosis is a degenerative illness, statistically associated with old age, many times patients have risk factors associated with this. Thus ozone therapy helps them by protecting the cardiovascular system by its antithrombosis effect, by the increase of tissue oxygenation and the lowering of heart attack and deep vein thrombosis. It also decreases the blood sugar levels and prevents the complications of diabetes. Patients who cannot be treated with transfusions because of physiological reasons, can benefit from systemic ozone administration through rectal insuflations.
The recovery of the articular tissue is done by intra and periarticular injections with ozone or with plasma concentrate. The patient’s blood is collected in a special container that is centrifuged afterwards and the separated plasma is bubbled with ozone. The plasma concentrate rich in P.R.P has an essential property: it activates the tissues’ natural recovery mechanisms. The ozone increases the release rate of these growth factors in the plasmatic concentrate, so that the result of the procedure should be faster, more obvious and more enduring than in a normal intervention. Through this procedure the platelet plasma intensifies certain essential biological processes, such as colagenesis, osteogenesis and angiogenesis. Another purpose of the plasma-ozone mixture is by the oxygenation secondary to intraarticular injections by the increase of the bactericidal and phagocytic capacity of the immune system.
The effect on pain and stiffness is given by the effect of secondary messengers of the ozone on the areas affected by arthrosis. The injected ozone inhibits the degradation of the arachidonic acid in the prostaglandins and reduces the quantity of chemical compounds that favour inflammation, at the same time with a relief of pain. The blood flow is low in the affected joint and the diminishing of the oxygenated blood flow increases the local inflammation. Local hypoxia produces pain. The ozone increases local oxygenation through several mechanisms. Directly, by dividing the molecule in an ozone molecule and a free radical (that combines with another radical, thus generating another molecule in a series), but also indirectly, by the increase of 2,3 diphosphoglycerate, by releasing the degree of release of oxygen in the tissues from the oxyhemoglobin. In this way, although there is less oxygen, it will be released faster and in higher percentage, therefore reducing the pain induced by hypoxia. Having a strong muscle relaxant effect, the ozone therapy acts on the muscles that stiffen the joint, thus relaxing them after a long period of contracture. In this way, the joint can be used more by the patient and the pain is reduced significantly.


The treatment of arthroses with ozone and thrombocyte enriched plasma does not promise to work wonders, but it has visible results on the patients’ quality of life. The elimination of pain, the increase of articular mobility, or the recovery of synovial fluid have been noticed constantly for over 40 years of this practice. In 1 st and 2 nd degree arthroses, the cartilage recovery is complete, and in the more serious ones, namely those of 3 rd and 4 th degree, the aim of the treatment is to stop de evolution of the disease and to prolongue the interval between crises. The ozone treatment is an individualized one, according to the stage of the stage of the illness and to the patient’s general state. Both the ozone injections and plasma are very well tolerated, and the pain appears only for a brief period of time, sctrictly at the point of inoculation.

With no allergies or side effects, the ozone treatment is recommended mostly to prevent the abuse of anti inflammatory or painkiller medication, as well as for the improvement of the patient’s general state of health.